A simple-minded 60-year-old is reunited with her half brother, a cranky pharmacist.

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After the death of her mother, who had protected her from the world, Nénette (Josianne Balasko), a simple-minded woman who thinks at the level of a little girl, discovers in a letter the identity of her father, a pharmacist in Angers. In hopes of escaping being sent to an institution, she goes off in search of him. But instead of her father, she finds her half-brother, Paul (Michel Blanc), who turns out to be a bitter man who took over his father's business instead of following his dream of becoming a pianist. Paul is less than thrilled at the arrival of his “embarrassing” half-sister. Refusing to take her in, he is instead visited by a nice bit of karma: under the influence of drugs for one day, Paul is generous, happy and sensitive. The next morning, however, once the drug has worn off, his nasty side comes back...

One envies Michel Blanc his drug-induced euphoria, which would be the only sensible way to digest the bitter pill that is Demi-soeur – a plethora of improbable and sticky-sweet situations. A bad trip is in store for all who dare swallow the marketing campaign and see this movie.